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Type: Proceedings Papers
Published: 2022-11-30
Page range: 29–31
Abstract views: 205
PDF downloaded: 172

Our life companions: the human follicular mite Demodex folliculorum

Ecology and Evolutionary Biology Section, School of Biological Sciences, University of Reading, United Kingdom
School of Natural Sciences, Bangor University, Bangor, Wales, United Kingdom, Institute and Museum of Natural Sciences, Faculty of Natural and Exact Sciences, National University of San Juan, San Juan, Argentina
follicular mite Demodex folliculorum


We carry them in our skin pores through our entire life, from birth to death.  We offer them shelter and in return, they tidy-up our pores.  We go on with our busy day life and they sleep.  They wake up when we go to sleep and while we are deeply dreaming, they move around, visit other pores and mates, and reproduce.  Despite being our ‘very own’ life companions, until recently, we knew very little about their struggle.


  1. Amitay-Laish, I., Solomon-Cohen, E., Feuerman, H., Didkovsky, E., Davidovici, B., Leshem, Y.A., Pavlovsky, L., Reiter, O., Mimouni, D., Hodak, E. & Segal, R. (2022) Facial demodicosis in the immunosuppressed state: A retrospective case series from a tertiary referral center. International Journal of Dermatology, 61, 1245–1252.

  2. Baghad, B., El Fatoiki, F.Z., Benhsaien, I., Bousfiha, A.A., Puel, A., Migaud, M., Chiheb, S. & Ailal, F. (2021) Pediatric demodicosis associated with gain-of-function variant in STAT1 presenting as rosacea-type rash. Journal of Clinical Immunology, 41, 698–700.

  3. Bakacak, Z., Kaplanoglu, M., Bakacak, M. & Çelik, T. (2020) Demodex folliculorum mite infestation in gynecological cancers: A case control study. European Journal of Gynaecological Oncology, 41, 583–586.

  4. Casas, C., Paul, C., Lahfa, M., Livideanu, B., Lejeune, O., Alvarez-Georges, S., Saint-Martory, C., Degouy, A., Mengeaud, V., Ginisty, H., Durbise, E., Schmitt, A.M. & Redoules, D. (2012) Quantification of Demodex folliculorum by PCR in rosacea and its relationship to skin innate immune activation. Experimental Dermatology, 21, 906–910.

  5. Dursun, A.T., Bayramgürler, D; Demirsoy, E.O., Aktürk, A.S., Kiran, R. & Sayman, N. (2022) Could there be an association between Hashimoto’s thyroiditis and demodex infestation? Journal of Cosmetic Dermatology.

  6. El Bassiouni, S.O., Ahmed, J.A.A., Younis, A.I., Ismail, M.A., Saadawi, A.N. & Bassiouni, S.O. (2005) A study on Demodex folliculorum mite density and immune response in patients with facial dermatoses. Journal of the Egyptian Society of Parasitology, 35, 899–910.

  7. Forton, F.M.N. & De Maertelaer, V. (2021) Which factors influence Demodex proliferation? A retrospective pilot study highlighting a possible role of subtle immune variations and sebaceous gland status. Journal of Dermatology, 48, 1210–1220.

  8. Foley, R., Kelly, P., Gatault, S. & Powell, F. (2021) Demodex: A skin resident in man and his best friend. Journal of the European Academy of Dermatology and Venereology, 35, 62–72.

  9. Grigoryan, O.M., Moskvina, T.V., Sklyar, L.F., Galkina, I.V., Beniova, S.N. & Shchelkanov, M.Y. (2018) [Demodecosis in HIV-infected patients]. Meditsinskaya Parazitologiya i Parazitarnye Bolezni, 2018, 50–57.

  10. Karabay, E.A. & Çerman, A.A. (2020) Demodex folliculorum infestations in common facial dermatoses: Acne vulgaris, rosacea, seborrheic dermatitis. Anais Brasileiros de Dermatologia, 95, 187–193.

  11. Kokaçya, M., Kaya, Ö., Çöpoðlu, Ü. & Elmacioðlu, S. (2016) Prevalence of Demodex spp among alcohol-dependent patients. Cukurova Medical Journal, 41, 259–263.

  12. Martinot, M., Korganow, A.S., Wald, M., Second, J., Birckel, E., Mahe, A., Souply, L., Mohseni-Zadeh, M., Droy, L., Tarabeux, J., Okada, S., Migoud, M., Puel, A. & Guffroy, A. (2021) Case report: a new gain-of-function mutation of STAT1 identified in a patient with chronic mucocutaneous candidiasis and rosacea-like demodicosis: an emerging association. Frontiers in Immunology, 12, e760019.

  13. Molho-Pessach, V., Meltser, A., Kamshov, A., Ramot, Y. & Zlotogorski, A. (2020) STAT1 gain-of-function and chronic demodicosis. Pediatric Dermatology, 37, 153–155.

  14. Pinsenschaum, L., Chan, D.H.L., Vogelnest, L., Weber, K. & Mueller, R.S. (2019) Is there a correlation between canine adult-onset demodicosis and other diseases? Veterinary Record, 185, 729.

  15. Pormann, A.N., Vieira, L., Majolo, F., Johann, L. & da Silva G.L. (2021) Demodex folliculorum and Demodex brevis (Acari: Demodecidae) and their association with facial and non-facial pathologies. International Journal of Acarology, 47, 396–403.

  16. Ricardo-Gonzalez, R.R., Kotas, M.E., O’Leary, C.E., Singh, K., Damsky, W., Liao, C., Arouge, E., Tenvooren, I., Marquez, D.M., Schroeder, A.W., Cohen, J.N., Fassett, M.S., Lee, J., Daniel, S.G., Bittinger, K., Diaz, R.E., Fraser, J.S., Ali, N., Ansel, K.M., Spitzer, M.H., Liang, H.-E. & Locksley, R.M. (2022) Innate type 2 immunity controls hair follicle commensalism by Demodex mites. Immunity, 55, 1891–1908.e12

  17. Sáez-de-Ocariz, M., Suárez-Gutiérrez, M., Migaud, M., Farrill-Romanillos, O.P., Casanova, J.L., Segura-Mendez, N.H., Orozco-Covarrubias, L., Espinosa-Padilla, S.E., Puel, A. & Blancas-Galicia, L. (2020) Rosacea as a striking feature in family members with a STAT1 gain-of-function mutation. Journal of the European Academy of Dermatology and Venereology, 34, e265–e267.

  18. Second, J., Korganow, A.-S., Jannier, S., Puel, A. & Lipsker, D. (2017) Rosacea and demodicidosis associated with gain-of-function mutation in STAT1. Journal of the European Academy of Dermatology and Venereology, 31, e542–e544.

  19. Seyhan, M.E., Karincaoðlu, Y., Bayram, N., Aycan, O. & Kuku, I. (2004) Density of Demodex folliculorum in haematological malignancies. Journal of International Medical Research, 32, 411–415.

  20. Shamriz, O., Lev, A., Simon, A. J., Barel, O., Javasky, E., Matza-Porges, S., Shaulov, A., Davidovics, Z., Toker, O., Somech, R., Zlotogorski, A., Molho-Pessach, V. & Tal, Y. (2021) Chronic demodicosis in patients with immune dysregulation: An unexpected infectious manifestation of Signal transducer and activator of transcription (STAT)1 gain-of-function. Clinical and Experimental Immunology, 206, 56–67.

  21. Smith, G., Manzano-Marin, A., Reyes-Prieto, M., Antunes, C.S.R., Ashworth, V., Goselle, O. N., Jan, A.A.A., Moya, A., Latorre, A., Perotti, M.A. & Braig, H.R. (2022) Human follicular mites: Ectoparasites becoming symbionts. Molecular Biology and Evolution, 39, msac125.

  22. Trama, I.C., Arévalo, J., Alvarado, M.E. & Baliña, G.E. (2018) Rosácea granulomatosa en paciente HIV. A propósito de un caso. [Granulomatous rosacea in HIV patient. A case report.] Revista Argentina de Dermatología, 99, 71–80. 

  23. Yamaoka, T., Murota, H., Tani, M. & Katayama, I. (2014) Severe rosacea with prominent Demodex folliculorum in a patient with HIV. Journal of Dermatology, 41, 195–196.

  24. Yazisiz, H., Çekin, Y., Sezer, Ý., Bostan, F. & Koçlar, F.G. (2020) Demodex species frequency and risk factors in patients with rheumatoid arthritis. Archive of Rheumatology, 35, 376–384.

  25. Yüksel, S. & Yüksel, E.P. (2020) Increased Demodex density in patients hospitalized for worsening heart failure. Journal of Personalized Medicine, 10, e39.

  26. Ziaja‐Sołtys, M., Kołodziejczyk, M., Rymgayłło‐Jankowska, B., Wróbel‐Dudzińska, D., Suchodoła‐Ratajewicz, E., Szlonzak, D., Żarnowski, T. & Bogucka‐Kocka, A. (2021) Massive demodicosis of the eyes in a patient with Sjögren syndrome: A case report. Acta Parasitologica, 66, 677–681.

  27. Zeytun, E. (2017) Demodex (Acari: Demodicidae) infestation in the elderly and its relationship with the skin parameters such as moisture, pH, and temperature: A cross-sectional study. Turkish Journal of Geriatrics, 20, 142–150.

  28. Zhang, W., Chen, X., Gao, G., Xing, S., Zhou, L., Tang, X., Zhao, X. & An, Y. (2021) Clinical relevance of Gain- and Loss-of-Function germline mutations in STAT1: A systematic review. Frontiers in Immunology, 12, e654406.